TOMOCOMD-CAMPS and Protein Bilinear Indices: Novel Bio-Macromolecular Descriptors for Protein Research. I. Predicting Protein Stability Effects of a Complete Set of Alanine Substitutions in Arc Repressor
نویسندگان
چکیده
Unit of Computer-Aided Molecular “Biosilico” Discovery and Bioinformatic Research (CAMD-BIR Unit), Faculty of Chemistry-Pharmacy. Central University of Las Villas, Santa Clara, 54830, Villa Clara, Cuba. Institut Universitari de Ciència Molecular, Universitat de València, Edifici d'Instituts de Paterna, Poligon la Coma s/n, E-46071 Valencia, Spain. Unidad de Investigación de Diseño de Fármacos y Conectividad Molecular, Departamento de Química Física, Facultad de Farmacia, Universitat de València, Spain. Department of Physiology, Medical School “Faustino Pérez Hernández”, Km # 3 Circumvallation, Sancti-Spíritus, Cuba.
منابع مشابه
Protein quadratic indices of the "macromolecular pseudograph's alpha-carbon atom adjacency matrix". 1. Prediction of Arc repressor alanine-mutant's stability.
This report describes a new set of macromolecular descriptors of relevance to protein QSAR/QSPR studies, protein's quadratic indices. These descriptors are calculated from the macromolecular pseudograph's alpha-carbon atom adjacency matrix. A study of the protein stability effects for a complete set of alanine substitutions in Arc repressor illustrates this approach. Quantitative Structure-Stab...
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تاریخ انتشار 2008